Category Archives: Drugs

New Study Says THC Reduces Meth-Induced Brain Damage

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A new study “investigated the neuroprotective effect of Δ9-THC on METH-induced neurotoxicity by examining its ability to reduce astrocyte activation and nNOS overexpression in selected brain areas”. In layman’s terms they investigated if THC can reduce or prevent brain damage caused by meth. The answer: Yes, THC can reduce or prevent brain damage caused by meth.

Δ9-THC is an active compound in cannabis AKA marijuana.

The abstract explains that “Methamphetamine (METH) is a potent psychostimulant with neurotoxic properties. Heavy use increases the activation of neuronal nitric oxide synthase (nNOS), production of peroxynitrites, microglia stimulation, and induces hyperthermia and anorectic effects.”

The researchers “results indicate that Δ9-THC reduces METH-induced brain damage via inhibition of nNOS expression and astrocyte activation through CB1-dependent and independent mechanisms, respectively.”

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New Study Says THC Reduces Meth-Induced Brain Damage by AlternativeFreePress.com is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

(Source: http://www.ncbi.nlm.nih.gov/pubmed/24844285)

High CBD Medical Marijuana To Be Grown In Colorado & Exported As Industrial Hemp

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Charlotte’s Web is a high CBD strain of medicinal cannabis with less than .03% THC, enabling it’s breeder to classify the plants with the state of Colorado as hemp instead of medical cannabis. This allows The Stanley Brothers to grow at a much larger scale and apparently opens up the possibility of exporting Charlotte’s Web.

Research into CBD has shown 84% success in reducing a child’s seizure frequency while taking cannabidiol-enriched cannabis. Of these, two (11%) reported complete seizure freedom, eight (42%) reported a greater than 80% reduction in seizure frequency, and six (32%) reported a 25-60% seizure reduction. Other beneficial effects included increased alertness, better mood, and improved sleep. Side effects included drowsiness and fatigue.

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High CBD Medical Marijuana To Be Grown In Colorado & Exported As Industrial Hemp by AlternativeFreePress.com is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Sources:

1. Charlotte’s Web medical cannabis soon to be widely available to Colorado children http://www.thedenverchannel.com/news/local-news/charlottes-web-medical-cannabis-soon-to-be-widely-available-to-colorado-children

2. Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy. http://www.ncbi.nlm.nih.gov/pubmed/24237632

The three deadliest drugs in America are all totally legal

German Lopez
Vox: May 19, 2014

As the US debates drug policy and marijuana legalization, there’s one aspect of the war on drugs that remains perplexingly contradictory: some of the most dangerous drugs in the US are perfectly legal.

[…] with a big qualification: it’s not a perfect comparison across the board. One driver of absolute tobacco and alcohol deaths is that both substances are legal and easily available. Other substances would most likely be far deadlier if they were as available as tobacco and alcohol.

[Editor’s Note: Other substances are currently cut with random filler ingredients, replaced with unknown drugs and sold by criminal organizations without safety warnings to people of all ages including children. Currently illegal substances would almost certainly be far less deadly if they were regulated as tobacco and alcohol.]

But it’s already established that it takes less relative doses to die from alcohol than it does to die from marijuana and even cocaine. An American Scientist analysis gauged the toxicity of drugs by comparing a drug’s effective dose — the amount it takes to get a desired effect — to its deadly dose. The analysis found alcohol is deadly at 10 times its effective dose, while heroin is deadly at five times, cocaine is deadly at 15 times, and ingested marijuana is deadly at more than 1,000 times. (In practical terms, it’s nearly impossible to overdose to death on marijuana because a user would most likely pass out before reaching a fatal dose.)

The direct death and overdose rates, however, leave out other factors that could lead to health and socioeconomic issues. Alcohol in particular is widely associated with various issues — more crime and traffic accidents, for example — that harm both users and society as a whole.

On top of the nearly 26,000 deaths brought on by detrimental health effects, alcohol caused more than 10,000 traffic fatalities in 2010.

In the latest year of data available for drugged driving (2009), the National Highway Traffic Safety Administration found alcohol in 32 percent of deadly traffic accidents. Other drugs, in comparison, were present in about 18 percent of deadly traffic accidents. (About 37 percent of drivers killed in an accident weren’t tested for drugs, though.)

Again, some of this is a matter of access. If other drugs were as easily available as alcohol, they could cause more deadly traffic accidents than they do today.

But it’s not really disputed that alcohol is one of the most dangerous drugs on the road. Columbia University researchers previously found alcohol increases the risk of a traffic accident 13 times over, while other drugs double to triple the risk and the detection of marijuana in particular less than doubles the risk.

One point of caution with all of these numbers: it’s much more difficult to measure how marijuana impairs drivers than it is to measure how alcohol impairs drivers, since marijuana stays in the system for much longer.

Even when accounting for other factors, alcohol and tobacco are still more harmful than marijuana

A previous report published in The Lancet took a comprehensive look at 20 of the world’s most popular drugs and the risks they pose in the UK. A conference of drug experts measured all the factors involved — mortality, other physical damage, chance of developing dependence, impairment on mental functioning, effect on crime, and so on — and assigned each drug a score. What they concluded: alcohol is by far the world’s most dangerous drug to society as a whole.

What makes alcohol so dangerous? The health effects and drunk driving are two obvious problems. But there are other major issues rooted in alcohol-induced aggression and erratic behavior: injuries, economic productivity costs, family adversities, and even crime. (Alcohol is a factor in 40 percent of violent crimes, according to the National Council on Alcoholism and Drug Dependence.)

(read the full article on Vox)


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There is no “war on drugs” in Mexico, the government is part of the cartels

Award winning investigative journalist Anabel Hernández explains that you can’t say that there’s a “war on drugs” in Mexico, since the government is part of the drug cartels. The cartels control many areas of the government, and many areas of the country, and the government just pretends to fight them.

As Drug Cartels Threaten Her Life, Mexico’s Most Dangerous Journalist Uncovers More Dark Truths

Nick Alexandrov
Substance: May 12, 2014

The Mexican investigative journalist Anabel Hernández is recognized worldwide as one of the most important reporters on the War on Drugs. Over two decades, she has received numerous awards for her work, including the 2012 Golden Pen of Freedom Award from the World Association of Newspapers and News Publishers. And just over a week ago, Reporters Without Borders placed Hernández on its list of “100 Information Heroes,” created to pay tribute to “the courage of the journalists and bloggers who constantly sacrifice their safety and sometimes their lives to their vocation.”

Hernández’s life has been at risk since she published Los Señores del Narco in 2010. The book—released in English last fall as Narcoland—breaks with conventional narratives of the “drug war,” which pit the Mexican government against drug traffickers. With unprecedented access to sources and tireless study of documents, Hernández instead makes the ironclad case that the war is a sham, its aims “limited to protecting the Sinaloa cartel.” The book exposes the intricate ties between Mexico’s leading drug traffickers and the leadership of the Mexican state. Published in 2010 to explosive effect, Narcoland remains one of the most widely read books in Mexico.

Since 2011, Hernández and her family have been the target of an escalating series of violent assaults. She has found decapitated animals on her doorstep. Gunmen attacked a family gathering. Last December about a dozen unidentified men armed with AK-47s invaded her house in Mexico City, terrorizing neighbors and injuring one of her bodyguards. She was lucky not to be home then, but the threats against Mexican journalists are deadly serious: Scores have been killed with impunity since 2000. Hernández’s courage, and her deep understanding—the product of years of relentless reporting—of the “drug war,” make hers an essential voice, one we ignore at our peril.

Nick Alexandrov: How did you begin covering the drug cartels?

Anabel Hernández: I’ve been a journalist since 1993, when the newspaper Reforma was founded in Mexico. Back then, Reforma didn’t hire experienced journalists, but journalism students, who were trained to become the kind of reporters Reforma needed. In 2000, when my father was kidnapped and killed [and the police refused to investigate unless the family paid them], my views on everything changed, and I started to investigate corruption in Mexico. The first case I discovered is known as “towelgate” [involving illegal use of funds for redecorating Fox’s houses], which occurred when Vicente Fox was president. Investigating that kind of common corruption eventually led me to the drug cartels.

For example, in 2005, a woman who’d worked for UNICEF told me that in an area called the “Golden Triangle,” between Sinaloa, Chihuahua and Durango, children were being forced to work in marijuana and poppy fields. So I went there. I was in Guadalupe y Calvo—a little town in the middle of the “Golden Triangle”—and that was the moment when I started to investigate drug trafficking. When I saw the fields, and how these people live—this little part of the biggest chain—I wanted to find out, What is happening here?

In 2000, when my father was kidnapped and killed [and the police refused to investigate unless the family paid them], my views on everything changed, and I started to investigate common corruption in Mexico. That led me to the drug cartels.

The conflict is often described as a battle between the Mexican government and the drug cartels. How do you understand that relationship? Is there a “drug war” in Mexico?

There is no “drug war.” I have been investigating the drug cartels for almost 10 years. I have access to a great deal of information—documents, court files, testimonies of members of the Mexican and US governments—and I can tell you that in Mexico there has never, never been a “war on drugs.” The government, from the mid-1970s until today, has been involved with the drug cartels.

First, the federal government tried to control the drug business, and was successful in doing so for several years. In Mexico, the early drug gangs were small, and given the freedom to operate. For many farmers, that was their job for generations. The gangs had to pay government officials, who would grant the smugglers permission to continue operating. And the federal police protected these gangs, and even helped them traffic drugs, to be sure the drugs would get to the US and not stay in Mexico. Meanwhile, the government tried to impose conditions on the traffickers, insisting that they not resort to violence.

But what I found after reviewing US congressional documents is that, starting in the late 1970s—and particularly by the time of the Iran-Contra scandal—the CIA helped connect Mexico’s small gangs with the big Colombian cartels. Mexico started to be a huge hub for trafficking between Colombia and the US. The Colombians arrived in Mexico, and used the Mexican gangs’ routes, which had previously been used for marijuana and poppies, to traffic cocaine.

When these Mexican gangs started trafficking cocaine, they became powerful, and their relationship with the Mexican government started to change. That was when the drug cartels formed, and these cartels were soon bribing mayors of little cities, governors, members of Congress.

So you can’t say that there’s a “war on drugs” in Mexico, since the government is part of the drug cartels. The cartels control many areas of the government, and many areas of the country, and the government just pretends to fight them.

Consider the case of El Chapo Guzmán [the head of the Sinaloa Cartel who was reportedly captured in the city of Mazatlán by Mexican marines in February]. I have documents showing that the authorities always knew where he was, all his different addresses, and they protected him—always! So it’s impossible for me to believe the official version of how El Chapo was captured. The government claimed, “Oh, Chapo was hiding at such-and-such an address,” but really the authorities, since 2007, had information about his properties.

There has never, never been a “war on drugs” in Mexico. The cartels control many areas of the government, and many areas of the country, and the government just pretends to fight them.

In Narcoland, you explain how a number of prominent drug traffickers in the past seem to have faked their own death in order to retire from organized crime. You also write that El Chapo “will quit when he feels like it, not when the authorities choose.” What’s your understanding of El Chapo’s alleged capture?

I’ve read many of the articles about that event, and mainly they give the official version, based on information provided by the Mexican and US governments–the DEA, for example. Meanwhile, in Chicago there are documents that prove connections between the Sinaloa Cartel and the DEA. So for me, it’s difficult to believe the official story, since I’ve been investigating these issues for years.

For example, on February 22, 2013, Mexican TV news networks, as well as the Guatemalan government, claimed that El Chapo had been killed in Guatemala. I immediately thought, “It cannot be possible!” But I decided to call one of my sources to check. When I asked him what he thought, he just started laughing, and asked me if I thought the cartel boss could be in Mexico and Guatemala at the same time.

It’s also impossible to believe that El Chapo was alone in Mazatlán. He could not even have been in Mazatlán, because Mazatlán is not a territory of the Sinaloa Cartel. It is a territory of the enemies of El Chapo Guzmán.

I also know that he was supposed to have three circles of security guards—circles of security guards. So there’s just one way in which the official story could be true, and that’s if El Chapo were betrayed by El Mayo Zambada [a fellow Sinaloa leader]. That would mean there’s a war going on within the Sinaloa Cartel—but right now there isn’t such a war. El Chapo wasn’t an insect. He was a really, really powerful man. Sinaloa is still the most important cartel. But even if El Chapo Guzmán has been captured and put in jail in the way the official version claims, it doesn’t mean anything, because the ties between the government and the Sinaloa Cartel are still there.

It’s impossible to believe that El Chapo was alone in Mazatlán. He could not even have been in Mazatlán, because Mazatlán is not a territory of the Sinaloa Cartel. It is a territory of the enemies of El Chapo Guzmán.

What is the situation like for reporters in Mexico? And what has your life been like since you started covering the cartels?

What’s happening to journalists in Mexico is terrible. More than 80 journalists have been murdered in the last 10 years. And no one is in jail for that—no one. The impunity is the main reason why journalists are still being killed. At the end of the day the government is essentially granting criminals permission to kill the journalists, which leaves us in a very insecure situation.

Since Vicente Fox was president, the federal government has started to create institutions that pretend—pretend—to take care of journalists. But these institutions don’t work. They have money, they have people, but they don’t work because the government doesn’t want them to work.

The president wouldn’t care if 100 journalists were killed tomorrow. Mexico is often thought of as a democracy, but really the government is very authoritarian. It doesn’t want transparency, it doesn’t want to be held accountable, and it doesn’t like uncomfortable questions. And that’s why the government wants to let these murders continue. And many things the government is saying to the international community—that it’s working to protect journalists and so on—are not true.

But the biggest problem isn’t that journalists are being attacked. The biggest problem is that people cannot get information. So right now you see many areas in Mexico where the media doesn’t want to inform people what is happening, and where the public doesn’t have the information necessary to make important decisions—like which politicians are corrupt and involved with the drug cartels, and which congressman or candidate is not. Without information, the public cannot make decisions. And now, in Mexico, we have black times.

President Vicente Fox wouldn’t care if 100 journalists were killed tomorrow. The Mexican government doesn’t want transparency, it doesn’t want to be held accountable, and it doesn’t like uncomfortable questions.

(Read the full interview at Substance)

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Mexico to legalize vigilantes fighting drug cartel

Alberto Arce
AP: May 10, 2014

Mexico’s government plans on Saturday to begin demobilizing a vigilante movement of assault rifle-wielding ranchers and farmers that formed in the western state of Michoacan and succeeded in largely expelling the Knights Templar cartel when state and local authorities couldn’t.

The ceremony in the town of Tepalcatepec, where the movement began in February 2013, will involve the registration of thousands of guns by the federal government and an agreement that the so-called “self-defense” groups will either join a new official rural police force or return to their normal lives and acts as voluntary reserves when called on.

The government will go town by town to organize and recruit the new rural forces.

“This is a process of giving legal standing to the self-defense forces,” said vigilante leader Estanislao Beltran.

But tension remained on Friday in the coastal part of the state outside the port of Lazaro Cardenas, where other “self-defense” groups plan to continue as they are, defending their territory without registering their arms. Vigilantes against the demobilization have set up roadblocks in the coastal town of Caleta.

“We don’t want them to come, we don’t recognize them,” vigilante Melquir Sauceda said of the government and the new rural police forces. “Here we can maintain our own security. We don’t need anyone bringing it from outside.”

With Saturday’s ceremony, a federal commissioner now in charge of the violence-plagued state hopes to end the “wild west” chapter of the movement, in which civilians built roadblocks and battled cartel members for towns in the rich farming area called the “Tierra Caliente,” or “Hot Land.”

The new rural forces are designed to be a way out of an embarrassing situation, in which elected leaders and law enforcement agencies lost control of the entire state to the pseudo-religious Knights Templar drug cartel. Efforts to retake control with federal police and military failed. Eventually government forces had to rely on the vigilantes because of their knowledge of where to find the cartel gunmen.

Since the commissioner, Alfredo Castillo, was named in January, federal forces have arrested or killed three of the main leaders of the Knights Templar. The fourth, Servando “La Tuta” Gomez, is in hiding and rumored to be in the rugged hills outside his hometown of Arteaga.

But the vigilante movement has been plagued by divisions, and its general council dismissed one of the founders, Dr. Jose Manuel Mireles, as its spokesman earlier this week because of an unauthorized video he released directed at President Enrique Pena Nieto. Another founder, Hipolito Mora, is in jail accused of the murder of two alleged rivals. Castillo told Mexico’s Radio Formula on Friday that he is also investigating claims that Mireles was involved in the killing of five vigilantes near Lazaro Cardenas on April 27.

Meanwhile, no one is giving up their guns, even assault weapons prohibited under Mexican law.

(Read the full article at Yahoo)


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British Journal of Pharmacology Study Says Cannabis May Treat Alzheimer’s Disease

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The British Journal of Pharmacology has published a new study which found that cannabis may treat neurodegenerative diseases such as Alzheimer’s disease. The study “details the mechanisms of neurodegeneration and highlights the beneficial effects of cannabinoid treatment.” Researchers studied the effects of cannabinoids in treating neurodegenerative diseases, finding that; “Through multiple lines of evidence, this evolutionarily conserved neurosignalling system has shown neuroprotective capabilities and is therefore a potential target for neurodegenerative disorders.”

Abstract:

In an increasingly ageing population, the incidence of neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease and Huntington’s disease are rising. While the aetiologies of these disorders are different, a number of common mechanisms that underlie their neurodegenerative components have been elucidated; namely neuroinflammation, excitotoxicity, mitochondrial dysfunction and reduced trophic support. Current therapies focus on treatment of the symptoms and attempt to delay the progression of these diseases but there is currently no cure. Modulation of the endogenous cannabinoid system is emerging as a potentially viable option in the treatment of neurodegeneration. Endocannabinoid signalling has been found to be altered in many neurodegenerative disorders. To this end, pharmacological manipulation of the endogenous cannabinoid system, as well as application of phytocannabinoids and synthetic cannabinoids have been investigated. Signalling from the CB1 and CB2 receptors are known to be involved in the regulation of Ca2+ homeostasis, mitochondrial function, trophic support and inflammatory status, respectively, while other receptors gated by cannabinoids such as PPARγ, are gaining interest in their anti-inflammatory properties. Through multiple lines of evidence, this evolutionarily conserved neurosignalling system has shown neuroprotective capabilities and is therefore a potential target for neurodegenerative disorders. This review details the mechanisms of neurodegeneration and highlights the beneficial effects of cannabinoid treatment.

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Source: British Journal of Pharmacology

Drugs are dangerous because they are illegal

Deaths from PMA, a more toxic form of ecstasy, are rising in the UK, but are almost unknown in countries that take a more pragmatic approach

A lethal ignorance: We could make drugs safer. We choose not to

Archie Bland
The Independent: March 2, 2014

The story of paramethoxyamphetamine, or PMA, is a neat parable of the war on drugs: a story of unintended consequences, a problem with viable solutions that are being ignored. Fixing this problem will not fix everything else. It is a relatively small part of the picture. But the logic that drives our response to it stands as a bottomlessly depressing symbol of the whole.

PMA has been around since the 1970s. It has some similar effects to MDMA (ecstasy), and it really came to prominence when efforts to crack down on that drug began to succeed in the mid-1990s. “It is a classic example,” says David Nutt, the former government adviser who now chairs the Independent Scientific Committee on Drugs. “Prohibition has led to the attempt to avoid prohibition, and therefore the production of more toxic substances.”

The purity of ecstasy tablets is often higher now than it was a few years ago. But unscrupulous dealers like the fact that PMA is cheaper, and it appears to be more prevalent than ever. There were no recorded deaths caused by PMA in the UK in 2009 or 2010; in 2011, there were five; in 2012, there were at least 17. The total for 2013 will be higher again. And yet, no one is using it on purpose. “There’s a gulf between what people are buying and what they think they are buying,” says Fiona Measham, a professor of criminology at Durham University and a leading authority on drug trends. “That gulf is growing.”

PMA is often described in newspaper headlines as “stronger” than MDMA. But it doesn’t get you higher. It’s just more toxic. What’s more, the effects of PMA take longer to come on, and a small increase can turn a relatively safe dose into a dangerous one. So people take a pill, think it’s poor quality ecstasy when they don’t feel anything after an hour, and take more to catch up. And then things go wrong.

Nicole Tomlinson was one of those who died in 2012. She had taken what she believed to be ecstasy when she was given it by her boyfriend, James Meaney; when nothing happened, they each took another two doses. Tomlinson was 19 years’ old. The couple’s child was two when she died. Last week, Meaney, 22, was sentenced to seven months in prison.

There is no question that Meaney bears a terrible responsibility for the fact that his child will grow up without a mother. But ultimately, his story is one of haplessness; on the other side of the equation is an approach so negligent that it is hard to distinguish from deliberate malice. The truth is, one simple step might have considerably reduced the chances of Nicole Tomlinson’s death, and that of many other victims of PMA: the provision of drug-testing facilities at clubs, so that researchers can find out which varieties of pill are not what they are said to be, and let people know.

This sort of scheme could be instituted this week without any legal difficulty. It is, of course, impossible to test every pill: you’d do well to operate in one or two big clubs in a particular city. But proper testing reshapes the market. It gives people the knowledge they need to make better decisions. Every headline on the Tomlinson story features the word “ecstasy”. But it wasn’t ecstasy that killed her. It was ignorance. If she had taken ecstasy, she would have been fine.

Such testing regimes run in Austria and the Netherlands. And to those involved, Britain’s resistance to a protocol with real evidence behind it seems perverse. “If we are not there, there is no information,” argues Rainer Schmid, a toxicologist and founder of Vienna’s “checkit!” project. “In Britain, it is a cynical approach, if you ask me. You know what is happening, and you say, no, we don’t want to solve it.”

The Home Office sees things differently. “We have no plans to introduce testing centres for illegal drugs,” it says. “Drugs are illegal because they are dangerous.”

(read the full article at The Independent)

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Treating PTSD with MDMA

Over 80% of subjects receiving MDMA-assisted psychotherapy in a pilot study no longer met the criteria for PTSD. A long-term follow-up study revealed that overall benefits were maintained an average of 3.8 years later.

Bob, a Vietnam vet struggling with PTSD for many years, was desperate for relief. When a number of his vet friends committed suicide, he knew he could be next. Then he saw a CNN report on the successes of MDMA-assisted psychotherapy in PTSD treatment. After being rejected from participation in the clinical trials conducted by the Mithoefers and MAPS, Bob decided to seek his own therapist, as well as his own MDMA. The journey took him to peyote ceremonies, Burning Man, and finally to a friend’s son, who was able to supply him with the illegal substance. Since completing the treatment, Bob has finally found relief from the crippling symptoms of PTSD. He claims the treatment saved his life.

Long after his experience in the Vietnam War, Bob Walker, like many veterans, still experiences the harsh effects of Post Traumatic Stress Disorder (PTSD). He had little luck in dulling the pain — until discovering MDMA, commonly known as ecstasy. Though it has a notorious reputation as a party drug, Walker and others are convinced that MDMA’s unique qualities have the potential to treat the debilitating symptoms of PTSD that other approaches can’t. The Verge investigates the past, present, and future of MDMA therapy.

Source

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Prohibition Causes Over 100 Overdoses in One State in Just 5 Days

Prohibition caused almost 120 people in Dallas and Austin to overdose on a synthetic drug in just 5 days.

K2 is sold as “synthetic marijuana”, despite the fact that K2 is not related to marijuana at all. The victims in Dallas were reportedly so sick that they had to be sedated.

K2’s formula is regularly changed to avoid illegality and users choose it because it is legally available and they will not risk arrest or fail a drug test.

“The compound is changed,” Stacey Davis, director of prevention programs for the Council on Alcohol & Drug Abuse in Dallas told WFAA. “And it’s not illegal, because they have not banned that compilation of the drug.”

WFAA concludes: “These changes not only make K2 easier to get, but often make it more addictive and deadly, in some cases.”

Prohibiting drugs results in more dangerous drugs being produced. If the goal of the war on drugs is to prevent dangerous drug use, it is counter-productive.

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Source: WFAA

A futile war on drugs that wastes money and wrecks lives

George Soros
FT: May 5, 2014

The war on drugs has been a $1tn failure. For more than four decades, governments around the world have pumped huge sums of money into ineffective and repressive anti-drug efforts. These have come at the expense of programmes that actually work such as needle exchanges and substitution therapy. This is not just a waste of money, it is counterproductive.

The London School of Economics has just completed perhaps the most thorough account of the war on drugs done to date. The conclusion, backed by five Nobel Prize-winning economists: it has done more harm than good.

Drug prohibition has created an immense black market, valued by some at $300bn. It shifts the burden of “drug control” on to producer and transit countries such as Afghanistan and Mexico. This approach also fails to grapple with a basic truth: drug markets are highly adaptive. Repress the business in one country and it springs up elsewhere.

Consider Colombia. When its law enforcement agencies made progress cracking down on the country’s cocaine trade, much of the criminal business and the violence that goes with it moved to Mexico. The LSE report estimates that after 2007, Colombia’s interdiction policies accounted for more than 20 per cent of the rise in Mexico’s murder rate.

Bogotá had a lot of mayhem to export. The explosion of the illegal drug market between 1994 and 2008 “explains roughly 25 per cent of the current homicide rate in Colombia. That translate into about 3,800 more homicides per year on average that are associated with illegal drug markets and the war on drugs”, according to the report. This type of violence takes a massive economic toll; corporations relocate, foreign investment dries up, industries decline and citizens flee in search of a better life.

The costs are not limited to producer countries; consumer nations suffer as well.

This is especially so in the US, which has less than 5 per cent of the world’s people but almost 25 per cent of the planet’s incarcerated population. Most are drug and other non-violent offenders for whom drug treatment and other alternatives to incarceration would probably prove cheaper and more effective in reducing recidivism and protecting society. Worldwide, 40 per cent of the 9m people who are incarcerated are behind bars for drug-related offences – and that figure is only likely to rise, as arrests of drug offenders in Asia, Latin America and west Africa are increasing steadily.

Despite the epic scale of human wreckage, services that could save lives and cut down on the costs to society go underfunded, or not funded at all.

(read the full article at FT)